
Hideyo Noguchi
A bacteriologist who helped fight infectious diseases through relentless effort.
Featured on Japan’s current 1,000-yen banknote, Hideyo Noguchi is a name almost everyone in Japan knows.
As a bacteriologist, he devoted himself to researching the causes of disease and was nominated for the Nobel Prize multiple times.
Here, we introduce Noguchi’s achievements, the life he lived, and what he was like through stories and memorable quotes.
Highlights
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Identified causes of various infectious diseases, helping advance the fight against them
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Recognized for his research and nominated for the Nobel Prize three times
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The first scientist to appear as a portrait on Japanese banknotes
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Born into poverty, he succeeded in medicine through relentless effort and support from those around him
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He also had a bold, unconventional side and was known to be careless with money and women
Hideyo Noguchi: Timeline
- 1876
- Born in Inawashiro, Fukushima, as the son of a poor farming family
- 1878
- Suffered a severe burn on his left hand
- 1883
- Enrolled in Mitsuwa Elementary School, but was bullied
- 1889
- Recognized for his ability by the vice principal of Inawashiro Higher Elementary School and enrolled there
- 1892
- Underwent surgery on his left hand, funded by donations from teachers and classmates
- 1893
- Began working as a live-in student assistant for the doctor who operated on his hand
- 1896
- Moved to Tokyo to obtain a medical license
- 1897
- Earned his medical license at age 20, but gave up clinical practice and began his path as a researcher
- 1898
- Changed his name from Seisaku Noguchi to Hideyo Noguchi
- 1900
- Traveled to the United States and worked as an assistant at the University of Pennsylvania
- 1904
- Transferred to the Rockefeller Institute for Medical Research
- 1905
- Succeeded in pure culture of the syphilis spirochete and became widely known in the medical world
- 1906
- Published findings such as identifying the cause of polio and the cause of rabies
- 1914
- Awarded a Doctor of Science degree by the University of Tokyo; nominated for the Nobel Prize in Physiology or Medicine
- 1915
- Nominated for the Nobel Prize in Physiology or Medicine for the second time
- 1918
- Dispatched to Ecuador to search for the cause of yellow fever
- 1920
- Awarded an honorary doctorate by the National University of San Marcos Faculty of Medicine; nominated for the Nobel Prize in Physiology or Medicine for the third time
- 1928
- Contracted yellow fever and died
Hideyo Noguchi’s Achievements
He’s famous for appearing on a banknote, but surprisingly few people know what Hideyo Noguchi actually achieved.
His greatest accomplishment is often described as clarifying the link between neurological disorders and infectious disease.
Specifically, he discovered the syphilis spirochete in the brains of patients with general paresis and in the spinal cords of patients with tabes dorsalis, proving both conditions are late-stage symptoms of syphilis.
Although later disputed, his pure culture of the pathogenic syphilis spirochete and his yellow fever research were also widely recognized as major achievements and highly regarded during his lifetime.
He also succeeded in identifying and culturing the pathogens of several other infectious diseases.
In recognition of his work, he was nominated for the Nobel Prize three times.

Hideyo Noguchi’s Life
Despite his remarkable achievements, Hideyo Noguchi’s life was far from smooth sailing.
Let’s look back on the path he took, rising from a poor farming family through extraordinary effort and support from those around him.
Bullied as a Child Due to a Severe Burn on His Left Hand
Hideyo Noguchi was born in 1876 in Inawashiro, Fukushima, as the son of a poor farming family.
At age one, he fell into an irori (sunken hearth), badly burning his left hand. His fingers fused and became deformed like a lump, leaving him unable to do farm work.
His mother urged him to make a living through learning, so he entered elementary school and studied hard.
Still, he endured daily bullying from classmates because of his hand.

Inspired by Surgery on His Left Hand, He Aimed to Become a Doctor
Life was difficult, but his talent was recognized by Sakae Kobayashi, vice principal of the local higher elementary school, who encouraged him to continue his studies.
When Noguchi was in his fourth year of the advanced course, teachers and classmates raised money for his surgery, and he underwent an operation on his left hand.
It didn’t fully heal, but he was moved by the power of medicine and decided to become a doctor.
After graduating, he worked as a live-in student assistant for the doctor who operated on him, learning medical fundamentals while working.
It was during this time that he first encountered bacteriology.

He Gave Up Clinical Practice and Chose the Path of a Bacteriologist
After moving to Tokyo, Hideyo Noguchi obtained his medical license at the young age of 20.
However, his impaired left hand made percussion, an essential clinical skill, difficult, so he chose the path of a bacteriologist.
Aiming to work on the world stage, he worked at various research institutes in Tokyo and immersed himself in research.
Later, relying on Dr. Simon Flexner, whom he had assisted as an interpreter and guide while Noguchi worked at a research institute, he moved to the United States in 1900.

Devoting Himself to Bacteriology at U.S. Research Institutes
Under Dr. Simon Flexner, he threw himself into research on snake venom.
When his results were recognized, he became an assistant in pathology at the University of Pennsylvania in 1902, and in 1903 he studied in Denmark.
At the State Serum Institute, he studied serology under Dr. Madsen.
After returning to the U.S. from Denmark in 1904, he became Dr. Flexner’s chief assistant at the Rockefeller Institute for Medical Research, and devoted himself even further to bacterial research.
People around him would ask, “When do you ever sleep?”

His Work to Uncover the Cause of Yellow Fever, and What Followed...
In 1918, he joined research on yellow fever, which was spreading across Central and South America, traveling to places such as Ecuador and Africa to investigate its cause.
Just as prevention and treatment were coming into view, Noguchi himself contracted yellow fever. Despite intensive treatment, he died at age 51.

Hideyo Noguchi’s Quotes
Hideyo Noguchi immersed himself in research so deeply that fellow scholars said they couldn’t tell when he ever slept.
The quotes he left behind, from someone you could call a genius of hard work, often center on perseverance and effort, and can hit especially hard when you’re facing adversity.
- Perseverance is bitter, but its fruit is sweet.
- Imagining yourself at rock bottom, then complaining and giving in to despair only blocks your success and disturbs your peace of mind.
- Effort, study, that is genius. The one who studies three, four, five times more than anyone else, that is genius.
Stories About Hideyo Noguchi
So far, we’ve focused on the uplifting parts of Hideyo Noguchi’s life and words.
But in reality, he was often careless with money and relationships, and left behind many wild, larger-than-life episodes.
Here are a few stories that show his very human side.
Kicked Out of His Lodging After Squandering Money
When he moved to Tokyo to earn his medical license, he raised about 800,000 yen from mentors and acquaintances. But after repeated nights at pleasure quarters and heavy drinking, he ran out of money and was kicked out of his lodging.
Later, he even spent the 10,000,000 yen he had saved to study in the U.S. on nights out with geisha, leaving many stories that show how careless he could be with money.
He Changed His Name to Avoid Being Mistaken for Someone Else
One day during his indulgent period, a friend introduced him to a novel titled “Tōsei Shosei Katagi.”
It tells the story of a medical student, Nonoguchi Seisaku, who comes to Tokyo and falls into a self-indulgent life of chasing women.
Noguchi was shocked at how closely it resembled his own life, and how similar the protagonist’s name was to his former name, Seisaku Noguchi.
Not wanting people to think he was the model for the character, he changed his name from Seisaku Noguchi to Hideyo Noguchi.
He Had Someone Else Adopted to Make the Name Change Possible
There’s also a story behind how he changed his name from Seisaku Noguchi to Hideyo Noguchi, because in those days, changing your name wasn’t easy.
So he found another person named Seisaku and had him adopted into the Noguchi family living near his home.
Then, claiming it was confusing to have two people named “Seisaku Noguchi,” he petitioned to change his own name.
Spots Connected to Hideyo Noguchi
Places built to honor Hideyo Noguchi’s legacy, as well as streets where he spent his youth, have become popular sightseeing spots.
If you want to know him more deeply, they’re well worth a visit.
1. Hideyo Noguchi Memorial Museum
The Hideyo Noguchi Memorial Museum is a museum opened in 1939 to commemorate his achievements. It consists of his birthplace and an exhibition hall. The exhibits use many photos, his personal belongings, robots, and more to introduce his life and research in an easy-to-understand way. Hands-on games that families can enjoy while learning about his work are also popular.
2. Nanokamachi Street, Hideyo Noguchi Youth Street
Nanokamachi Street and Hideyo Noguchi Youth Street are retro sightseeing streets in the heart of Aizuwakamatsu City. Lined with buildings from the Meiji, Taisho, and early Showa eras, a stroll here feels like stepping back in time. The two streets connect at a right angle, and walking the full route takes about 20 minutes (Approx. 1.2 km).
Turn right at Ōmachi Yotsukado from Nanokamachi Street to continue onto Hideyo Noguchi Youth Street. A short walk south, you’ll find the former Kaio Clinic, where Noguchi underwent surgery for his hand burn as a boy. Today, it’s the Hideyo Noguchi Youth Museum. It’s a fitting starting point for the man who would later become a great doctor.
Photos
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Hideyo Noguchi
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An image of the bacteria Hideyo Noguchi devoted himself to studying
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An image of the irori (sunken hearth) that caused the burn
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An image of the surgery Noguchi received on his left hand
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An image of a research institute
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The 1,000-yen banknote featuring Hideyo Noguchi’s portrait
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The 1,000-yen banknote featuring Hideyo Noguchi’s portrait
Hideyo Noguchi: Profile
- Name
- Hideyo Noguchi
- Born
- 1867
- Died
- 1928
- Age at death
- 51
- Place of birth
- Mitsuwa Village, Yama District, Fukushima (now Inawashiro)

